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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Tosyl phenylalanyl chloromethyl ketone ： ウィキペディア英語版 Tosyl phenylalanyl chloromethyl ketone | Section2 = | Section3 = }} Tosyl phenylalanyl chloromethyl ketone (TPCK) is a protease inhibitor. Its structural formula is 1-chloro-3-tosylamido-4-phenyl-2-butanone. ==Uses== TPCK is an irreversible inhibitor of chymotrypsin. Also inhibits some cysteine proteases such as caspase, papain, bromelain or ficin.〔Focus Biomolecules Catalog # 10-2290 TPCK. (), Retrieved on May 23. 2013.〕 It does not inhibit trypsin or zymogens. TPCK is observed covalently bound in the active site of Caspase 3 in the crystal structure of the complex solved in 2010.〔(Ganesan et al ). Acta Cryst F v67 p 842. PDB Entry 〕 The chloromethyl group reacts with the active site cysteine to form a covalent bond with the loss of the chlorine. TPCK is chosen for the chemical labelling of active histidine in enzyme analysis. The phenylalanine moiety is bound to the enzyme because of specificity for aromatic amino acid residues at the active site (as in chymotrypsin, in which it binds to the Histidine-57 residue in the active site). 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tosyl phenylalanyl chloromethyl ketone」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.